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Obesity-related changes in the drug eliminating organs, e.g., variations in hepatic enzyme activity and GFR, potentially warrant adjustments to the maintenance dosages (Gerhart et al., 2022a)

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She has served as lead investigator and author for trials investigating novel nutrient-stimulated hormone (NuSH)-based therapies for obesity including dual hormone receptor agonist, tirzepatide, a GIP/GLP-1 receptor agonist (Jastreboff, et al ., NEJM , 2022 and NEJM , 2024), triple hormone receptor agonist, retatrutide, a GIP/GLP-1/Glucagon receptor agonist (Jastreboff, et al ., NEJM , 2023), and a monthly monoclonal antibody peptide conjugate, maridebart cafraglutide, a GIP receptor antagonist GLP-1 receptor agonist (Jastreboff, et, al., NEJM, 2025)

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