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1,2 1,407 adults with BMI 30 kg/m 2 without diabetes were included in the trial

Although our analyses show that many of the proteomic perturbations resulting from semaglutide treatment are linked to changes in body weight and glycemia, the lack of a dose response on CVD risk with semaglutide 1.0 mg and 2.4 mg in STEP 2 supports semaglutide effects on CVD beyond weight loss

To further investigate the serious adverse events, this study included only reports that led to severe outcomes from the FAERS database for sensitivity analysis

Tirzepatide has a roughly five-day half-life, reaching steady state slightly faster

BMI 40+: 12 mg

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