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Glucose-dependency of the insulin stimulatory effect of glucagon-like peptide-1 (7-36) amide on the rat pancreas

Example registry listing (obesity + cardiovascular disease) One publicly listed Phase 3 study is NCT05882045 (TRIUMPH-3) , which evaluates efficacy and safety in participants with obesity and established cardiovascular disease

That mechanism is the leading explanation for the larger weight-loss numbers retatrutide has produced in trials

[DOI] [PubMed] [Google Scholar] Saremi A, Tulloch-Reid M, Knowler WC
95% CI 0.62 to 7.17) (Fig