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Unrealised Expectations Despite progress, several anticipated 2025 milestones did not come to fruition: Regulatory progress stalled: FDAs obesity drug guidance, published in draft form in January 2025, remains unfinalised, whilst EMA has yet to update its 2016 guideline

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Dosing in kidney and liver disease is also covered, along with drug interactions.

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However, alternative delivery methods such as vaping, which heats the plant without combustion, are becoming more common