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Treatment of autoimmune diabetes in NOD mice by Toll-like receptor 2 tolerance in conjunction with dipeptidyl peptidase 4 inhibition

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These interviews have been lightly edited for clarity

In a subgroup of participants with indicators of prediabetes, some of the two-drug combination therapy groups had 100% reversion to normoglycemia among participants with prediabetes at baseline, essentially moving them to a nonprediabetes status

Others respond less robustly, even with optimal dose, diet, and exercise