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Track any cycle changes or symptoms, and resist the urge to dramatically increase calories

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Place the vial in the middle of a shelf, away from the back wall (which can sometimes be colder and risk freezing) and away from the door

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The magnitude of the decline in NT-proBNP was less marked than the 18% decrease observed in the STEP-HFpEF trials, 36 potentially because of our much lower baseline value and because of the smaller decrease in body weight produced by semaglutide (ie, 8%9%) compared with tirzepatide

p values below 0.05 were considered statistically significant