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Activation of GLP-1R induces an increase in intracellular Ca 2+ in 40% of NTS astrocytes, while selective inhibition of astrocyte function in NTS abolishes exendin-4-induced inhibition of food intake (Reiner et al., 2016)

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(Kamat AA, senior author)

Liraglutide alleviates diabetic cardiomyopathy by blocking CHOP-triggered apoptosis via the inhibition of the IRE- pathway

Reported across doses, often related to reduced food intake during the stepping-up phase