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Although total lean mass (baseline 51.3 kg) was also reduced by 2.3 kg and 1.5 kg with semaglutide and canagliflozin, respectively (estimated treatment difference: 0.78 [1.61, 0.04]), the proportion of lean mass (baseline 59.4%) increased by 1.2%- and 1.1%-point, respectively (estimated treatment difference 0.14 [0.89, 1.17])

reduced form)-dependent buffering systems, several constraint-sensitive metabolic processesincluding NAD partitioning, amino aciddependent antioxidantanabolic coupling, micronutrient-dependent enzymatic activity, and bile acidmediated absorptionmay become functionally limiting

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