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The findings indicate that HFpEF is associated with various comorbidities, such as obesity, diabetes mellitus, and hypertension, which contribute to endothelial dysfunction

Wegovy (semaglutide) Injector 1.7 mg/0.75 mL, 4 Pens Per Box is a medication used for chronic weight management in adults with obesity or excess weight who have at least one weight-related health condition, such as high blood pressure, type 2 diabetes, or high cholesterol. It is used in combination with a reduced calorie diet and increased physical activity. Wegovy is a glucagon-like peptide-1 (GLP-1) receptor antagonist and works by slowing down digestion, decreasing appetite, and increasing feelings of fullness, which helps with weight loss. It is administered as a subcutaneous injection and comes in a package of 4 pens for 4 weeks of treatment

Researchers have identified a small-molecule compound that appears to counteract weight gain and metabolic damage in mice exposed to a long-term Western diet.

Doctors prescribe this drug for blood sugar control when diet, exercise, or metformin are not enough, or as a first-line therapy under new medical guidelines.