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A few highlights: Accelerated eGFR decline during the year preceding a heart failure event Slower decline afterward but still exacerbated A parallel between eGFR slope and NYHA class, suggesting the kidney may be signaling congestion early These findings call for a shift in practice: instead of relying on static eGFR thresholds, tracking its trajectory over time could help us identify at-risk patients sooner and intervene before hospitalization

63 Likewise, the incretin mimetic geniposide has been reported to mitigate H 2 O 2 -mediated death in PC12 cells

(2) Study design (clinical trial registration number)

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Semaglutide: review and place in therapy for adults with type 2 diabetes

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