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End-capped -helices as modulators of protein function

Impaired branched chain amino acid oxidation contributes to cardiac insulin resistance in heart failure

[DOI] [PubMed] [Google Scholar] 91.Barrera J.G., Jones K.R., Herman J.P., DAlessio D.A., Woods S.C., Seeley R.J

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33 A retrospective analysis of 164 patients with T2D who switched to OW semaglutide from either liraglutide or dulaglutide (REALiSeDM), having been on the initial GLP1RA for at least 3 months, also showed a reduction in HbA 1c following the switch

Together, these data suggest that GLP1 receptors are sufficient to mediate all the effects of GLP1, but the effects of endogenous GLP1 on eating behaviour are: (1) compensated for in the knockout mice by functionally overlapping/redundant mechanisms