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Key points: - Weight loss in Parkinson's disease was associated w/ greater cognitive decline, whereas weight gain was associated w/ slower motor progression in previous longitudinal studies

From the approval of Orlistat (Xenical) in 1999, which focused on reducing dietary fat absorption, to the emergence of highly effective incretin-based therapies such as liraglutide (Saxenda), semaglutide (Wegovy), and tirzepatide (Zepbound), we have witnessed a fundamental shift in how obesity is understood and treated