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Medical Weight Loss with GLP-1s: What They Are, How They Work, and Whether Theyre Right for You GLP-1 medications such as semaglutide and tirzepatide have become some of the most talked-about tools in medical weight loss and metabolic health

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However, very few studies support their efficacy

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This systematic review and meta-analysis evaluated the effects of oral semaglutide, compared with placebo, on cardiometabolic risk factors in overweight and obese adults with or without diabetes

The study also reported a 42% lower risk of psychiatric hospitalizations and work absences during periods when patients were taking semaglutide compared with periods when they were not.
