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doi: 10.3389/fendo.2018.00576 93 SteenselsSDepoortereI

Epidemiological data from the International Diabetes Federation (IDF) indicate that the global burden of diabetes affected approximately 463 million adults in 2019, with projections estimating a dramatic increase to 700 million cases by 2045 2

Acute illness or poor oral intake Vomiting, diarrhoea or reduced food intake during illness can increase hypoglycaemia risk, particularly if medication doses are not adjusted

doi: 10.1016/S0140-6736(21)00213-0 68 FriasJPDeenadayalanSErichsenLKnopFKLingvayIMacuraSet al

Key exclusion criteria included diabetes, previous or planned surgical treatment for obesity, use of medications that promote weight loss or gain, or a weight change of more than 5 kg in the three months before screening

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