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Both the gut and liver are implicated as the main sources of metformin-related lactate production

As well, treatment with alogliptin (20 mg/kg/day), a selective DPP-4 inhibitor, showed similar anti-inflammatory effects in the injured arteries of low-density lipoprotein receptor-deficient mice [69]

doi: 10.1007/s00535-013-0846-6 39

In this trial, at 60 weeks, the exenatide group showed a significant improvement in MDS-UPDRS Part III scores compared to the placebo group among the 62 recruited patients (80)

Even a 10-15% reduction in upper back muscle mass can increase the mechanical load on cervical structures by up to 40%

They both slow digestion, affect appetite centers in the brain, and improve glucose metabolism