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This is the actual biological process where continuous stimulation of the GLP-1 receptor causes it to become less responsive

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These findings demonstrate what may be possible when we treat obesity and impact overall health, and what this could mean for people living with obesity and its related complications." TRIUMPH-1 included an overarching trial for adults with obesity and two nested basket trials: one for knee osteoarthritis pain and one for moderate-to-severe obstructive sleep apnea

[14] In patients with diabetes, overly aggressive glycemic control or inadequate adjustment of concurrent diabetes medications (particularly insulin or sulfonylureas) may result in hypoglycemia or relative hypoglycemia, even if glucose values remain within normal range