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Diabetes leads to a significantly accelerated incidence of various related macrovascular complications, including peripheral vascular disease and cardiovascular disease (the most common cause of mortality in diabetes), as well as microvascular complications such as kidney disease and retinopathy

GLP-1 analogs are widely used to treat patients with type 2 diabetes in recent years

However, PKA inhibition but not GLP-1R blockade eliminated the protective effects of metformin on endothelial function

By 2030, the global prevalence of obesity is expected to reach one billion

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