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Correspondence: Link to online article: Conflicts of interest: JRFW has acted as a consultant, speaker or advisory board member for, or his institution has received research funding from, Dr Falk, Enyo, GEHealthcare, Intercept, Metacrine, Novartis, Pendopharm and Prometheus

Abnormal relationships between the neural response to high- and low-calorie foods and endogenous acylated ghrelin in women with active and weight-recovered anorexia nervosa

Analyses of plasma biomarkers, collected from all participants, and a CSF sub-study (planned n = 210) will explore semaglutide effects on AD biomarkers and neuroinflammation

However, with increased options of affordable semaglutide, higher-efficacy innovative originals and once-daily orals on the horizon, patients may be increasingly willing to mix therapies so tailor the benefit and side effect profile of their treatment

The mechanism by which GLP-1 RAs potentially increase suicide or suicide attempts is unclear but may involve an overactivation of the hypothalamic-pituitary-adrenal (HPA) axis [7], rapid weight loss [8], and reduced expression of brain-derived neurotrophic factor which may link weight changes to heightened anxiety and suicidal risk [9]

Nutrition drives durability, with a clear protein goal and fiber intake supporting fullness and lean mass