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Participants characteristics Participants in the exit interviews were similar to those in the main trial in terms of age (mean [standard deviation, SD] 51.02 [12.4] and 48.2 [12.7] years, respectively), sex (female: 47.5 % and 48.0 %, respectively), and race (white: 85.0 % and 88.0 %, respectively [12]

Of these, 41 studies met the inclusion criteria through database searching, and one additional eligible clinical study was identified through manual reference tracking, for a total of 42 included studies

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As Young remembers, 'We couldnt predict weight loss or weight gain with these drugs.' One of the challenges was that enhanced insulin secretion normally increases body weight

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