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Description

Rates are broadly comparable, typically affecting 10-20% of patients

Some practitioners start with semaglutide (more data) and switch to tirzepatide (broader mechanism) if response is insufficient

Pregnancy and breastfeeding : Semaglutide should not be used during pregnancy and should be discontinued at least two months before a planned pregnancy

While these outcomes are based on large clinical trials (STEP 1 and SURMOUNT-1), weight loss should still be approached with realistic expectations, personalized goals, and ongoing support

More importantly, the magnitude of improvement in body weight resulted from increased energy expenditure and decreased food intake, which led to a remarkable loss of fat mass