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The tirzepatide doses of 10 and/or 15 mg demonstrated superiority compared to placebo for the coprimary endpoints percentage body weight reductions from baseline at week 72 and the proportion of patients achieving 5% body weight reduction at week 72

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Research published in major obesity journals demonstrates that approximately 50% of weight lost on GLP-1 therapy returns within 12 months of discontinuation, with some patients gaining back even more due to metabolic adaptation

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This thorough approach ensures new patients receive appropriate care while meeting regulatory requirements for medication transitions

[DOI] [PubMed] [Google Scholar] 471.Guccio N., Alcaino C., Miedzybrodzka E.L., Santos-Hernandez M., Smith C.A., Davison A., et al