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These factors support GLP-1 use in diabetes and obesity treatment

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98 The transportation of GLP-1 or its ligands through the central nervous system (CNS) may be mediated by astrocytes and tanycytes

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Active GLP-1 Forms Generated by the Gut and Brain In the gut and brain, proglucagon is then further processed into various proglucagon peptides, including active GLP-1 8,9