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In pancreatic -cells, this results in enhanced glucose-dependent insulin exocytosis the incretin effect and also drives insulin gene expression and -cell survival and proliferation via the PI3K/Akt pathway

The Journal of Clinical Investigation, 124, 44734488

The FDA shortage determinations that supported widespread compounded semaglutide and tirzepatide availability resolved in 2025

Glucagon Suppression: The hormone reduces glucagon release from pancreatic alpha cells, which helps prevent excess glucose production by the liver and supports more stable metabolic function throughout the day

Ryan et al., 2020) and genera Akkermansia (Chen et al., 2018

*Correspondence: Frederik Flindt Kreiner, [email protected] This article was submitted to Clinical and Translational Physiology, a section of the journal Frontiers in Physiology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers