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Moreover, it might be of clinical relevance whether endogenous acetylcholine or adenosine via cardiac M 2 -cholinoceptors or via cardiac A 1 -adenosine receptors may reduce positive chronotropic effects of retatrutide in patients

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These findings suggest a novel therapeutic pathway for IIH management, where GLP-1R agonists may offer dual benefits in weight reduction and headache relief [58]

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