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In principle, this is not surprising, because models of complex diseases such as brain diseases, as a rule, either involve some of the known mechanisms of the pathogenesis of these diseases, or simply mimic individual symptoms, but never fully reproduce the pathogenesis and symptoms of the disease

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Toward defining the preclinical stages of Alzheimers disease: recommendations from the National Institute on Aging-Alzheimers Association workgroups on diagnostic guidelines for Alzheimers disease

However, the response to such medications varies for each patient