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These effects typically peak during dose titration and improve over time but cause 20-50 percent of patients to discontinue treatment within the first year

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[DOI] [PMC free article] [PubMed] [Google Scholar] 61.Asmar M, Simonsen L, Madsbad S, Stallknecht B, Holst JJ, and Blow J, Glucose-Dependent Insulinotropic Polypeptide May Enhance Fatty Acid Re-Esterification in Subcutaneous Abdominal Adipose Tissue in Lean Humans, Diabetes 59, no

Improved metabolic health markers (blood pressure, cholesterol, blood sugar) become evident