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Doctors reference the STEP clinical trials, which demonstrated approximately 15% average weight loss with semaglutide versus 2.6% with placebo over 68 weeks

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The compound itself simultaneously activates three key hormone receptors: GLP-1 (glucagon-like peptide-1), GIP (glucose-dependent insulinotropic polypeptide), and GCGR (the glucagon receptor)

Much further work is also needed to establish how GIPR antagonism decreases body weight (centrally or peripherally mediated) and how GIPR and GLP-1R agonism synergizes to decrease body weight

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