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BMC Endocrine Disorders, 23, 256

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It was added because rodents developed thyroid C-cell tumors in animal studies, and that raised enough concern to justify a strong warning label

This personalization accounts for the relationship between body mass and peptide distribution

For a side-by-side of how this compares to the dual and single agonists, see our breakdown of Retatrutide vs Semaglutide vs Tirzepatide

The discovery of the GLP-1 receptor and natural GLP-1 has allowed medicinal chemists to develop a longer acting GLP-1