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Description
Until the data of the SURPASS-CVOT trial are available, tirzepatide will most likely have a place in the algorithm of T2D therapy for patients with obesity and T2D that have the therapeutic aim to normalize glycemia and decrease body weight

For some, meaningful weight loss remains frustratingly difficult

[DOI] [PMC free article] [PubMed] [Google Scholar] [121].Dungan KM, Povedano ST, Forst T, Gonzalez JG, Atisso C, Sealls W, Fahrbach JL, Once-weekly dulaglutide versus once-daily liraglutide in metformin-treated patients with type 2 diabetes (AWARD-6): a randomised, open-label, phase 3, non-inferiority trial, Lancet, 384 (2014) 13491357

This has resulted in industry developments like the rise of retail care, telehealth, and concierge care

Comprehensive Weight Loss Support (Beyond GLP-1s) Not everyone needs GLP-1 medicationsand the best results come from a personalized, sustainable approach

Absolute insulin responses were not augmented, but they were sustained in face of the improved glycaemia which, together with the lower glucagon levels could be suggestive of an improved islet function related to the observed increase in intact GLP-1 levels (33)
