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In that trial, 4,286 (24.3%) of patients had heart failure with 1,347 of those patients having heart failure with reduced ejection fraction dwarfing the small numbers studied in the initial trials mentioned previously

Patients with a BMI of 30, or a BMI of 27 with one weight-related medical condition (like high blood pressure or type 2 diabetes), are candidates for weight loss medications like GLP-1s

In summary, GLP-1RAs provide substantial weight loss and cardiometabolic benefits but may compromise skeletal muscle integrity, whereas exercise supports muscle maintenance and functional health, though its effect on weight reduction is typically modest compared with pharmacotherapy

On the other hand, much evidence from large retrospective cohorts with endoscopic evaluation of gastric content has proven the association between incretin-based therapy exposure and increased retained gastric content [21]

This is exactly why physician supervision and personalized nutritional guidance are not optional add-ons

doi:10.1111/dom.13339 8
