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In the meantime, there has also been the first attempt to create a gene therapy that could integrate a GLP-1 secreting transgene directly into pancreas beta cells

Similar to the results obtained with acute injection, repeated liraglutide treatment (six injections over 2 weeks) of alcohol-experienced male rats has been shown to decrease both alcohol consumption and preference for alcohol (Vallof et al., 2015)

Zudem zeigen Studien, dass nach dem Absetzen der Therapie hufig ein Jo-Jo-Effekt eintritt das verlorene Gewicht kehrt zurck, wenn keine tiefgreifende Lebensstilnderung erfolgt

Large trials have demonstrated that these agents reduce cardiovascular events in patients with cardiovascular disease and improve outcomes in heart failure, kidney disease and metabolic dysfunction-associated steatohepatitis