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Anti-obesity drugs should be offered as initial treatment of overweight and obesity for adults with weight-related comorbidities and for those at high risk of complications, and as a component of first-line treatment for patients with obesity and overweight without comorbidities

Semaglutide and Tirzepatide are two widely studied compounds in laboratory research focused on incretin signaling and metabolic pathway regulation

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However, weight change from baseline to week 52 was statistically significantly in favour of semaglutide 1.0 mg

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Emerging evidence also supports its expanding role in the management of non-alcoholic fatty liver disease (NAFLD), heart failure, polycystic ovary syndrome (PCOS), obstructive sleep apnea (OSA), alcohol use disorder (AUD), and Alzheimers disease