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Dynamic macronutrient meal-equivalent menu method: towards individual nutrition intervention programs

For example, investigators found that orexigenic effects of systemically administered ghrelin (also known as the hunger hormone) were abolished in CB 1 receptor knockout mice 40 , and pharmacological blockade of the CB 1 receptor, via rimonabant administration, attenuated ghrelin-induced activation of the mesolimbic dopamine system a key pathway involved in reward processing 41

Maintenance is not a passive phase

The modulation of enteric neuronal function and serotonin signaling by GLP-1R agonists contributes to reduced visceral hypersensitivity and pain [52, 53]

doi: 10.1074/jbc.M205401200

They mimic hormones your gut naturally releases after eating