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As Novo Nordisk's subscription plans launch, cash-paying patients can still pay $149 per month for the lower doses of the pill, which are 1.5 and 4 milligrams

To be considered for broader use, semaglutide's cardiovascular benefits may need to be compared to those of other drugs like SGLT2 inhibitors, which are also known to have heart-protective effects

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Importantly, semaglutidetreated patients experienced sustained weight loss (mean ~10.2% vs 1.5% at 208 weeks) and improvements in waist circumference and waisttoheight ratio, anthropometric changes that track with cardiometabolic risk reduction