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Three nonrandomized studies showed a higher incidence of elevated RGC content in 1011 patients who used GLP-1RAs ( OR 6.08

This degradation is catalyzed by the ubiquitous serum enzyme dipeptidyl peptidase 4 (DPP-4), which is produced both locally in the intestine and by circulating white blood cells

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Semaglutide dose-dependently reduced liver enzymes, and resulted in greater NASH resolution (reduced ballooning and lobular inflammation) without worsening of fibrosis, as compared with placebo after 72 weeks of treatment

Notably, sex-related differences in weight reduction became more pronounced with increasing degrees of weight loss and in trials with longer treatment durations [55]