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Purity: 98% (HPLC) COA available upon request

1 Several peptidic drugs have been approved including one in pill form, the oral semaglutide

2.2.1 Trial 1 (Ethinylestradiol/Levonorgestrel) Subjects received a once-daily OC (Microgynon containing ethinylestradiol 0.03 mg and levonorgestrel 0.15 mg) in three 8-day periods

P =0.0003])

Residues from M371 ECL3 to G377 ECL3 have been mutated to Ala (with A376 to Gly), showing only a modest effect upon GLP-1 pharmacology (Dods and Donnelly, 2015)

SGLT2 Inhibitors The EMPA-REG OUTCOME and CANVAS studies have shown favourable all-cause mortality and cardiovascular outcomes.11,12 Meta-analyses of CVOTs confirmed the cardiovascular benefits.17,18 Three studies from landmark CVOTs further stratified patients according to baseline characteristics.21,22,23 The benefits of SGLT2 inhibitors were more apparent in patients with a history of HF and reduced ejection fraction.22,23 However, baseline risk was higher in this group of patients, possibly accounting for higher absolute risk reductions in cardiovascular outcomes
