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GIP amplifies that effect while also improving how your body handles insulin and glucose

B6 mice fed with a normal fat diet (Normal Diet) or HFD (DIO) received the following treatment regimens: saline (Saline), scExe4 donor DNA-loaded LNP (Donor), or scExe4 donor DNA plus Cas9-coding DNA-loaded LNP (Donor+Cas9)

Diabetes Res Clin Pract 2015;110:2637

All constructs were confirmed by Sanger sequencing

Insulin resistance exacerbated pathological PD features which contributed to disease progression via increases in -synuclein accumulation in dopaminergic neurons, oxidative stress, and mitochondrial dysfunction