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Currently, there is no direct evidence that GLP-1RA use contributes to progression of pancreatic cysts to PDAC, but this remains an important knowledge gap for future investigations considering the high prevalence of pancreatic cysts in the general population (~ 10% by age 50 and ~25% by age 70) 56

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In the cholesterol biosynthesis pathway, expression of genes such as lanosterol synthase ( Lss ), cytochrome P450, family 51 ( Cyp51 ), NAD(P) dependent steroid dehydrogenase-like ( Nsdhl ) and 7-dehydrocholesterol reductase ( Dhcr7 ) were decreased