exendin-4 glp-1 The glucagon-like peptide-1 analogue reverses impaired intracellular Ca2 + signalling in steatotic hepatocytes Differences between the GLP-1-and exendin-4(9-39)-bound

Because the fraction was incapable of decreasing blood glucose, Kimball and Murlin hypothesized that the hyperglycemic effect resulted from a secreted factor, one that antagonizes insulin's hypoglycemic effect

The chronic nature of obesity means that long-term management strategies may need to evolve over time, and flexibility in approach supports better outcomes than rigid adherence to initial plans that prove unsustainable

TABLE 2 Pharmacologically underexploited metabolic peptidereceptor systems beyond incretins: native peptide pharmacology underdeveloped despite validated biology

Mutt's laboratory's peptide production funded a great deal of his research activity (Jrnvall, Agerberth, Zasloff)

Nuts and seeds are dependable choices

doi: 10.1001/JAMA.2023.24945