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Heat map for top 5 genes per enriched pathway in ( b ) Gipr Syn / vehicle-treated and Gipr fl/fl mGIPR-Ab/P1-treated mice, and ( d ) Glp1r Wnt1 / vehicle-treated and Glp1r fl/fl mGIPR-Ab/P1-treated mice

Ther Adv Endocrinol Metab (2021) 12:204201882198923

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Factors to consider include the method of consumption (smoking, vaping, edibles), frequency of use, the presence of other medical conditions, and concurrent medications

GLP-1 agonists slow stomach emptying and can worsen diarrhea in this population by allowing more time for abnormal bile acid handling in the small intestine

In the TRED-HF trial, patients were randomly assigned to phased withdrawal or continuation of GDMT over 6 months