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doi: 10.1038/nature22378

The researchers conducted experiments using adult male mice

146 CPPs can facilitate cargo internalization by directly conjugating with the C-terminus of proteins or peptides, creating nanocomplexes through hydrophobic/electrostatic interactions, or covalently linking with nucleic acid molecules

Starting Weight and BMI People with higher starting weights tend to lose more weight in absolute terms (total pounds) but may lose a similar or slightly lower percentage of body weight compared to those starting at a lower weight

Future research should include prospective studies with polysomnographic data, pharmacodynamic exploration of CNS effects, and stratification by psychiatric and neurologic comorbidities