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CB1 is widely expressed in the central nervous system (CNS) and brain, but is also expressed in peripheral tissues such as adipose tissue, skeletal muscle, and in the liver, kidney, gut and pancreas

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Tirzepatide and retatrutide (single molecule): A single engineered molecule that hits multiple receptors simplifies the formulation to one compound with one pharmacokinetic profile, and allows the balance of receptor activation to be tuned at the molecular-design level