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Blood was sampled throughout the day for analysis of plasma hormone and substrate concentrations

Independently of these peripheral actions, GLP-1RAs show direct cerebral effects in animal stroke models, such as reduction of infarct volume, apoptosis, oxidative stress, neuroinflammation, excitotoxicity, bloodbrain barrier permeability, and increased neurogenesis, neuroplasticity, angiogenesis, and brain perfusion

The explosive demand for GLP-1 (glucagon-like peptide-1) receptor agonists, driven by their efficacy in treating obesity, has outpaced supply and created a dynamic market landscape

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However, cardiovascular safety trials in type 2 diabetes patients, the majority presenting cardiovascular disease and excess weight, showed that GLP-1 receptor agonists were indeed capable of decreasing cardiovascular risk