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GLP-1 medications should not be taken during pregnancy, when trying to conceive, or while breastfeeding, due to limited human safety data

(13) Disruption of this balancesuch as elevated RANKL or reduced OPGis linked to increased bone resorption and delayed fracture healing, particularly in diabetes

We provide nutritional guidance tailored to GLP-1 therapy, lifestyle coaching for sustainable habits, progress tracking and accountability, and integration with other wellness services if desired

This hypothesis is also supported by our HIF-1 knockdown experiments, in which GLP-1R signalling-induced gene expression and metabolic adaptations were only partially perturbed, pointing to a possible involvement of additional transcriptional factors

Researchers at Penn are already planning a multisite clinical trial that will evaluate whether GLP-1 therapy can reduce breast cancer incidence among high-risk women, including breast cancer survivors