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Description
The risk of gastrointestinal adverse events is increased with GLP-1RA therapy but these effects tend to be mild-to-moderate and transient, and are not the reason for observed weight loss
Jackson C et al, Applying COM-B to medication adherence: A suggested framework for research and interventions

Dysregulation of inflammasomes is closely linked to numerous human diseases, including neurodegenerative diseases, cancers, and vascular diseases
Oral contraceptives tirzepatide slows gastric emptying, which may reduce the absorption and effectiveness of oral birth control pills

In clinical trials, the results are modest but real

Glucagon-like peptides GLP-1 and GLP-2 derive from transcription product of the proglucagon gene gcg located on chromosome 2