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Causes and Management GLP-1 receptor agonists are widely prescribed in the UK for type 2 diabetes and weight management

Tin Wui Wong Lijing Wang College of Life Sciences and Technology, China Pharmaceutical University, Nanjing, Jiangsu, Peoples Republic of China Correspondence: Lijing Wang, College of Life Science and Technology, China Pharmaceutical University, 639 Longmian Avenue, Jiangning District, Nanjing, Jiangsu, Peoples Republic of China, Tel +86 182 860 69474, Email [email protected]

Centrally, these GLP-1 RAs modulate appetite and reduce the intake and cravings for high-calorie food and alcohol

GLP-1RA Mechanism of Action GLP-1 (glucagon-like peptide-1) is a hormone secreted by the intestinal tract during feeding, which enhances insulin secretion and inhibits glucagon secretion in a glucose concentration-dependent manner, and delays gastric emptying to reduce the amount of food eaten through central appetite suppression

Those with a BMI of 30 or higher or a BMI of 27 accompanied with one or more weight-related health conditions, may be eligible for Tirzepatide treatment

In the brain, both GIP and GLP-1 are thought to be involved in memory formation as well as the control of appetite [10]