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& Rainey, W
[cited 2026 April 27] 16
Adding GIP activation on top of GLP-1 is the mechanism behind tirzepatide's efficacy advantage over semaglutide
Ozempic and Wegovy (and Rybelsus, which is oral semaglutide) are GLP-1 receptor agonists (glucagon-like peptide-1 receptor agonists, commonly referred to as GLP-1s) and are the only FDA-approved drugs that contain the active ingredient semaglutide
In healthy individuals, GIP accounts for approximately 60-70% of the total incretin effect on insulin secretion, while GLP-1 contributes 30-40%
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