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Both medications contain the same active ingredient: semaglutide

Though with similar effects as some pre-existing drugs (semaglutide, liraglutide, exenatide, etc.) targeting diabetes and obesity, tirzepatide is considered a first-in-class medication for demonstrating action on both the glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) receptors

Patients receiving semaglutide also achieved a whopping 12.5% reduction in their total body weight over the 72-week study period

Orlistat (Alli) is a well-known fat absorption inhibitor that prevents the body from absorbing about 30% of the fat consumed during a meal

So it clearly has been, if you will, its been instantiated

Shen, T