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Semaglutide is a medication that was initially approved for Type 2 diabetes, but is now allowed to be prescribed for weight loss too

In late 2024, the Biden Administration proposed to significantly expand Medicare and Medicaid coverage of AOMs to include obese patients without co-morbidities

This is relevant for the short-acting GLP-1 agonists, whereas tachyphylaxis rapidly develops for the long-acting agonists [8]

Liraglutide deserves mention as the older option

Updated February 2026 Tirzepatide vs Semaglutide: Complete Comparison (2026 Data) Tirzepatide vs semaglutide with SURMOUNT-5 head-to-head data: -20.2% vs -13.7% weight loss

Average baseline weight ranged from 72.2 to 121 kg, with a median weight of 95.8 kg