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If they overlap in your system, you get additive stimulation of those receptors, and the result is not better efficacy

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GO analysis revealed that these upregulated genes were predominantly associated with hormone-mediated signalling pathways, peptide transport, macroautophagy regulation, cellular glucose homeostasis, cell growth regulation, positive insulin secretion regulation, cellular response to glucose stimulus, hypoxia response, MAP kinase kinase kinase activity, and ATP metabolic process regulation (Fig